Addiction is a chronic (often life-long) relapsing brain disorder characterized by compulsive and uncontrollable drug[note 1]-seeking behaviour despite harmful consequences.[note 2] It is usually accompanied by signs of physical dependence such as the appearance of a withdrawal syndrome after abrupt discontinuation of the drug. Addiction is believed to be a form of maladaptive memory, which seems to involve a multitude of different neurotransmitters and brain functions and involve irreversible changes in brain structure and function. Amongst the various factors that appear to influence risk of addiction genetics, environment, etc. One of the major neurotransmitters that appear to be implicated is glutamate, which is involved in neuroplasticity.
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- The TRIP database provides clinical publications about evidence-based medicine.
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