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Acetylcysteine (brand names – Acetadote, Mucomyst) is a cysteine (which is an amino acid) derivative that has beneficial effects on cocaine addiction in humans.[1] It is believed to work via modulating glutamate release in the brain, due to the fact it is metabolised into cystine, which drives the cystine-glutamate antiporter in the brain.[1] It is traditionally used to treat paracetamol overdose, due to its ability to readily metabolise into glutathione, the body’s chief antioxidant scavenger.[1] Paracetamol-induced hepatotoxicity is mostly due to oxidative stress incurred by a toxic metabolite of paracetamol. Acetylcysteine is also used to treat chest congestion and has recently shown some ability to improve symptoms in those with psychiatric disorders.[1]

Reference listEdit

  1. 1.0 1.1 1.2 1.3 Berk, M; Malhi, GS; Gray, LJ; Dean, OM (March 2013). "The promise of N-acetylcysteine in neuropsychiatry.". Trends in Pharmacological Sciences 34 (3): 167–77. doi:10.1016/j.tips.2013.01.001. PMID 23369637.

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