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The 5-HT2A receptor is a serotonin receptor that is believed to mediate the hallucinogenic effects of psychedelics such as lysergide (LSD) and psilocybin (found in hallucinogenic mushrooms). This receptor also mediates the super-potent anti-inflammatory effects of psychedelics.[1][2] Atypical antipsychotics also inversely agonize this receptor, along with mianserin, mirtazapine, nefazodone, setiptiline and trazodone. These agents alleviate the negative and cognitive symptoms of schizophrenia, this it likely achieves by increasing dopamine release in the mesocortical pathway.[3] 5-HT2A inverse agonism may also alleviate extrapyramidal side effects of D2 antagonism by increasing dopamine release into the nigrostriatal pathway which controls movement, and may alleviate the psychotic symptoms seen in Parkinson's disease psychosis without compromising movement control.[3] It also allows the JC virus access to brain cells.[4]

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Reference listEdit

  1. Yu, B; Becnel, J; Zerfaoui, M; Rohatgi, R; Boulares, AH; Nichols, CD (November 2008). "Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency.". The Journal of Pharmacology and Experimental Therapeutics 327 (2): 316–23. PMID 18708586. doi:10.1124/jpet.108.143461. 
  2. Nau F, Jr; Yu, B; Martin, D; Nichols, CD (2013). "Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo.". PloS One 8 (10): e75426. PMID 24098382. doi:10.1371/journal.pone.0075426. 
  3. 3.0 3.1 Brunton, LL; Chabner, BA; Knollmann, BC, ed. (2010). "16: Pharmacotherapy of Psychosis and Mania". Goodman & Gilman's Pharmacological Basis of Therapeutics. (12th ed.). New York, USA: McGraw-Hill Professional. ISBN 978-0-07-162442-8. 
  4. Elphick, GF; Querbes, W; Jordan, JA; Gee, GV; Eash, S; Manley, K; Dugan, A; Stanifer, M; Bhatnagar, A; Kroeze, WK; Roth, BL; Atwood, WJ (November 2004). "The human polyomavirus, JCV, uses serotonin receptors to infect cells". Science 306 (5700): 1380–3. PMID 15550673. doi:10.1126/science.1103492. 

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