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The 5-HT1A receptor is a serotonin receptor that is inhibitory in nature; it is widely distributed in the human brain with the highest concentrations found in the amygdala, cortical limbic areas, hippocampus and septum.[1] 5-HT1A agonists possess antidepressant, anxiolytic, analgesic, anti-aggressive, neuroprotective, cognitive effects (both pro-cognitive and cognition-impairing) and anti-craving, antiemetic and anticataleptic effects.[1] In fact, buspirone, a partial agonist at 5-HT1A is widely used for its anti-anxiety effects, although it has been used off-label to augment response to antidepressants and to treat resistant cases of ADHD. Other 5-HT1A partial agonists include the atypical antipsychotics perospirone and ziprasidone. 5-HT1A receptors are more heavily expressed in the brains of non-violent suicide victims.[1]

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  1. 1.0 1.1 1.2 Glennon, RA; Dukat, M; Westkaemper, RB (2000). Psychopharmacology - The Fourth Generation of Progress. New York, USA: Lippincott Williams & Wilkins. ISBN 978-0-78-170166-2. 

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