The 5-HT1A receptor is a serotonin receptor that is inhibitory in nature; it is widely distributed in the human brain with the highest concentrations found in the amygdala, cortical limbic areas, hippocampus and septum. 5-HT1A agonists possess antidepressant, anxiolytic, analgesic, anti-aggressive, neuroprotective, cognitive effects (both pro-cognitive and cognition-impairing) and anti-craving, antiemetic and anticataleptic effects. In fact, buspirone, a partial agonist at 5-HT1A is widely used for its anti-anxiety effects, although it has been used off-label to augment response to antidepressants and to treat resistant cases of ADHD. Other 5-HT1A partial agonists include the atypical antipsychotics perospirone and ziprasidone. 5-HT1A receptors are more heavily expressed in the brains of non-violent suicide victims.
- NCBI Bookshelf provides free book resources on this topic.
- PubMed provides review articles from the past five years (limit to free review articles or to systematic reviews)
- The TRIP database provides clinical publications about evidence-based medicine.